Simulation scenario 2

Setting description

Hormone_therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 272 0 0 0 TP53- & AR- 366 2 1 1 TP53+ 235 0 0 1 DRD+ 100 1 0 0 TEfus+ 161 0 0 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.544 0.000 0.000 0.000 TP53- & AR- 0.732 0.004 0.002 0.002 TP53+ 0.470 0.000 0.000 0.002 DRD+ 0.200 0.002 0.000 0.000 TEfus+ 0.322 0.000 0.000 0.004

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 96 70 77 TP53- & AR- 1 383 396 402 TP53+ 0 263 231 225 DRD+ 0 137 199 182 TEfus+ 0 224 203 231

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.192 0.140 0.154 TP53- & AR- 0.002 0.766 0.792 0.804 TP53+ 0.000 0.526 0.462 0.450 DRD+ 0.000 0.274 0.398 0.364 TEfus+ 0.000 0.448 0.406 0.462

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 18 16 24 10 TP53+ 72 12 27 19 DRD+ 0 0 0 0 TEfus+ 0 0 0 1

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.036 0.032 0.048 0.020 TP53+ 0.144 0.024 0.054 0.038 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.002

Errors & power

The overall error was 0.448.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.442             0.006             0.002             0.008 

The overall power was 0.544.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.544             0.000             0.000             0.000 

Median results at the end of the trial

By signature:

signature	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
all	graduation	0	0	272	0	0
	futility	70	0	0	77	96
	max_n	0	0	0	0	0
	n	154 (97, 249)	434 (366, 478)	132 (34, 264)	156 (94, 231)	148 (93, 236)
	n_unique	144 (90, 236)	408 (343, 449)	125 (32, 249)	145 (88, 215)	137 (86, 225)
	time_trial	36 (33, 36)	36 (36, 36)	32 (5, 36)	36 (32, 36)	36 (29, 36)
	time_stop	30 (20, 35)	NA (NA, NA)	10 (4, 30)	30 (20, 35)	28 (17, 35)
	post_p	0 (0, 0)	NA (NA, NA)	1 (1, 1)	0 (0, 0)	0 (0, 0)
	rate	0.114 (0.101, 0.13)	0.073 (0.067, 0.079)	0.038 (0.032, 0.045)	0.113 (0.101, 0.127)	0.114 (0.102, 0.129)
DRD+	graduation	0	0	100	0	1
	futility	199	0	0	182	137
	max_n	0	0	0	0	0
	n	53 (31, 81)	113 (91, 134)	26 (2, 56)	53 (32, 79)	42 (25, 71)
	n_unique	48 (29, 75)	105 (86, 125)	24 (1, 53)	50 (30, 74)	39 (22, 67)
	time_trial	36 (21, 36)	36 (36, 36)	36 (24, 36)	36 (21, 36)	36 (26, 36)
	time_stop	25 (17, 34)	NA (NA, NA)	24 (17, 33)	26 (16, 34)	27 (20, 34)
	post_p	0.02 (0, 0.14)	NA (NA, NA)	0.99 (0.77, 1)	0.01 (0, 0.14)	0.03 (0, 0.19)
	rate	0.115 (0.097, 0.142)	0.073 (0.062, 0.085)	0.037 (0.024, 0.054)	0.116 (0.097, 0.142)	0.115 (0.093, 0.151)
TEfus+	graduation	0	0	161	2	0
	futility	203	0	0	231	224
	max_n	0	0	0	1	0
	n	63 (33, 104)	154 (131, 179)	38 (8, 95)	60 (30, 98)	59 (32, 104)
	n_unique	58 (31, 95)	144 (121, 167)	35 (7, 89)	56 (29, 91)	55 (29, 97)
	time_trial	36 (21, 36)	36 (36, 36)	36 (15, 36)	36 (20, 36)	36 (17, 36)
	time_stop	26 (15, 33)	NA (NA, NA)	19 (11, 33)	26 (16, 34)	23 (15, 33)
	post_p	0.01 (0, 0.11)	NA (NA, NA)	1 (0.92, 1)	0.01 (0, 0.09)	0.01 (0, 0.1)
	rate	0.114 (0.096, 0.142)	0.072 (0.064, 0.082)	0.039 (0.028, 0.049)	0.115 (0.095, 0.142)	0.114 (0.095, 0.141)
TP53- & AR-	graduation	1	0	366	1	2
	futility	396	0	1	402	383
	max_n	24	0	18	10	16
	n	44 (25, 124)	173 (107, 204)	32 (19, 132)	42 (25, 115)	39 (25, 120)
	n_unique	42 (23, 121)	162 (97, 192)	30 (18, 125)	39 (24, 109)	35 (23, 114)
	time_trial	23 (13, 36)	36 (36, 36)	12 (7, 36)	22 (13, 36)	23 (14, 36)
	time_stop	20 (13, 31)	NA (NA, NA)	9 (6, 25)	19 (13, 32)	21 (13, 31)
	post_p	0.01 (0, 0.1)	NA (NA, NA)	1 (0.95, 1)	0.01 (0, 0.11)	0.01 (0, 0.09)
	rate	0.116 (0.096, 0.147)	0.072 (0.063, 0.083)	0.039 (0.03, 0.05)	0.115 (0.095, 0.146)	0.117 (0.098, 0.149)
TP53+	graduation	0	0	235	1	0
	futility	231	0	0	225	263
	max_n	27	0	72	19	12
	n	70 (34, 135)	202 (177, 225)	48 (13, 152)	70 (33, 134)	67 (32, 129)
	n_unique	64 (31, 130)	189 (165, 210)	45 (12, 142)	65 (31, 124)	62 (31, 120)
	time_trial	36 (19, 36)	36 (36, 36)	36 (10, 36)	36 (17, 36)	35 (15, 36)
	time_stop	26 (14, 34)	NA (NA, NA)	13 (9, 32)	24 (14, 34)	24 (12, 33)
	post_p	0 (0, 0.07)	NA (NA, NA)	1 (0.97, 1)	0.01 (0, 0.07)	0 (0, 0.07)
	rate	0.115 (0.097, 0.14)	0.073 (0.064, 0.082)	0.038 (0.029, 0.047)	0.113 (0.097, 0.137)	0.115 (0.096, 0.141)

By subgroup combinations:

subtype	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
—-	graduation	404	0	465	407	401
	futility	0	0	0	0	0
	max_n	24	0	18	10	16
	n	23 (8, 80)	111 (69, 134)	25 (15, 100)	20 (8, 74)	21 (9, 77)
	n_unique	21 (8, 77)	104 (62, 127)	24 (15, 95)	19 (7, 73)	19 (8, 74)
	post_p	0.06 (0, 0.27)	NA (NA, NA)	1 (0.88, 1)	0.07 (0.01, 0.3)	0.06 (0, 0.23)
	rate	0.118 (0.091, 0.166)	0.072 (0.061, 0.085)	0.039 (0.029, 0.054)	0.117 (0.089, 0.174)	0.119 (0.094, 0.181)
—+	graduation	418	0	472	432	423
	futility	0	0	0	0	0
	max_n	23	0	18	11	16
	n	6 (2, 18)	19 (10, 28)	4 (1, 13)	6 (2, 15)	7 (2, 18)
	n_unique	5 (2, 17)	17 (9, 26)	4 (1, 11)	5 (2, 15)	6 (2, 17)
	post_p	0.29 (0.12, 0.61)	NA (NA, NA)	0.85 (0.51, 0.98)	0.29 (0.12, 0.57)	0.27 (0.1, 0.53)
	rate	0.123 (0.072, 0.319)	0.073 (0.049, 0.105)	0.037 (0.013, 0.086)	0.122 (0.073, 0.371)	0.121 (0.082, 0.272)
–+-	graduation	234	0	371	228	269
	futility	0	0	0	0	0
	max_n	27	0	70	19	12
	n	16 (5, 53)	71 (57, 83)	22 (7, 68)	15 (5, 52)	14 (5, 52)
	n_unique	14 (5, 50)	67 (54, 78)	21 (7, 64)	14 (5, 50)	13 (5, 49)
	post_p	0.12 (0.02, 0.36)	NA (NA, NA)	0.99 (0.83, 1)	0.14 (0.02, 0.38)	0.12 (0.03, 0.37)
	rate	0.121 (0.089, 0.223)	0.074 (0.06, 0.09)	0.038 (0.026, 0.053)	0.118 (0.086, 0.21)	0.12 (0.087, 0.219)
–++	graduation	308	0	405	314	338
	futility	0	0	0	0	0
	max_n	26	0	67	18	12
	n	13 (4, 36)	46 (34, 57)	10 (2, 37)	11 (4, 33)	14 (6, 37)
	n_unique	12 (3, 35)	43 (31, 53)	10 (2, 35)	10 (3, 31)	12 (6, 35)
	post_p	0.16 (0.03, 0.44)	NA (NA, NA)	0.94 (0.57, 1)	0.18 (0.04, 0.5)	0.14 (0.03, 0.45)
	rate	0.121 (0.086, 0.242)	0.073 (0.056, 0.093)	0.04 (0.022, 0.07)	0.12 (0.081, 0.258)	0.118 (0.086, 0.2)
-+–	graduation	418	0	472	415	415
	futility	0	0	0	0	0
	max_n	24	0	18	10	16
	n	7 (3, 20)	19 (10, 26)	2 (0, 10)	8 (3, 18)	6 (2, 17)
	n_unique	7 (2, 19)	17 (9, 25)	1 (0, 9)	7 (3, 17)	5 (1, 15)
	post_p	0.28 (0.1, 0.58)	NA (NA, NA)	0.8 (0.49, 0.97)	0.27 (0.09, 0.55)	0.27 (0.1, 0.57)
	rate	0.126 (0.082, 0.32)	0.076 (0.051, 0.108)	0.037 (0, 0.097)	0.125 (0.082, 0.249)	0.137 (0.077, 0.405)
-+-+	graduation	429	0	478	438	435
	futility	0	0	0	0	0
	max_n	23	0	18	11	16
	n	7 (2, 18)	18 (11, 26)	2 (0, 7)	7 (3, 17)	6 (2, 17)
	n_unique	6 (2, 17)	17 (10, 25)	1 (0, 7)	7 (2, 16)	5 (1, 16)
	post_p	0.26 (0.08, 0.57)	NA (NA, NA)	0.78 (0.42, 0.95)	0.26 (0.1, 0.54)	0.3 (0.11, 0.6)
	rate	0.128 (0.084, 0.303)	0.072 (0.049, 0.107)	0.041 (0, 0.135)	0.125 (0.082, 0.289)	0.127 (0.075, 0.343)
-++-	graduation	294	0	392	276	296
	futility	0	0	0	0	0
	max_n	27	0	70	18	12
	n	5 (2, 12)	12 (7, 18)	2 (0, 9)	5 (2, 12)	4 (1, 11)
	n_unique	5 (2, 11)	12 (7, 17)	2 (0, 8)	5 (2, 11)	4 (1, 10)
	post_p	0.32 (0.15, 0.63)	NA (NA, NA)	0.77 (0.41, 0.96)	0.32 (0.14, 0.62)	0.34 (0.16, 0.62)
	rate	0.126 (0.073, 0.33)	0.074 (0.047, 0.121)	0.043 (0, 0.134)	0.129 (0.071, 0.359)	0.131 (0.069, 0.402)
-+++	graduation	343	0	415	346	352
	futility	0	0	0	0	0
	max_n	26	0	67	17	12
	n	5 (1, 12)	12 (8, 17)	2 (0, 9)	5 (2, 12)	4 (1, 11)
	n_unique	5 (1, 12)	12 (7, 16)	2 (0, 8)	5 (2, 11)	3 (1, 10)
	post_p	0.32 (0.13, 0.61)	NA (NA, NA)	0.77 (0.4, 0.94)	0.3 (0.14, 0.58)	0.34 (0.17, 0.6)
	rate	0.135 (0.071, 0.361)	0.072 (0.046, 0.112)	0.043 (0.004, 0.142)	0.134 (0.073, 0.409)	0.134 (0.067, 0.468)
+—	graduation	70	0	272	77	96
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	6 (2, 17)	22 (15, 28)	9 (1, 24)	6 (2, 16)	8 (3, 19)
	n_unique	6 (2, 16)	21 (14, 27)	8 (1, 22)	6 (2, 15)	8 (3, 18)
	post_p	0.27 (0.1, 0.57)	NA (NA, NA)	0.86 (0.47, 0.99)	0.28 (0.11, 0.59)	0.23 (0.09, 0.54)
	rate	0.131 (0.074, 0.355)	0.074 (0.05, 0.105)	0.041 (0.018, 0.085)	0.123 (0.071, 0.285)	0.124 (0.08, 0.252)
+–+	graduation	210	0	342	234	230
	futility	0	0	0	0	0
	max_n	0	0	0	1	0
	n	6 (2, 14)	17 (11, 23)	5 (1, 17)	5 (2, 15)	7 (3, 15)
	n_unique	5 (2, 13)	16 (10, 22)	4 (0, 15)	4 (2, 14)	6 (2, 14)
	post_p	0.31 (0.13, 0.62)	NA (NA, NA)	0.81 (0.46, 0.98)	0.3 (0.13, 0.58)	0.27 (0.1, 0.57)
	rate	0.124 (0.067, 0.332)	0.073 (0.049, 0.11)	0.042 (0.017, 0.095)	0.128 (0.075, 0.411)	0.126 (0.075, 0.288)
+-+-	graduation	234	0	371	228	269
	futility	0	0	0	0	0
	max_n	27	0	70	19	12
	n	6 (2, 15)	17 (11, 24)	3 (0, 14)	6 (2, 16)	6 (2, 15)
	n_unique	5 (2, 15)	16 (11, 22)	3 (0, 13)	6 (1, 15)	6 (2, 15)
	post_p	0.31 (0.13, 0.57)	NA (NA, NA)	0.8 (0.45, 0.97)	0.3 (0.12, 0.61)	0.25 (0.1, 0.57)
	rate	0.122 (0.074, 0.351)	0.073 (0.046, 0.108)	0.04 (0.012, 0.098)	0.126 (0.069, 0.354)	0.134 (0.082, 0.351)
+-++	graduation	308	0	405	314	338
	futility	0	0	0	0	0
	max_n	26	0	67	18	12
	n	6 (2, 14)	17 (11, 23)	3 (0, 14)	6 (2, 15)	6 (2, 15)
	n_unique	5 (1, 13)	15 (10, 22)	3 (0, 14)	5 (1, 14)	6 (2, 15)
	post_p	0.29 (0.13, 0.59)	NA (NA, NA)	0.82 (0.47, 0.97)	0.31 (0.12, 0.61)	0.28 (0.1, 0.57)
	rate	0.127 (0.072, 0.298)	0.073 (0.05, 0.109)	0.038 (0.014, 0.097)	0.126 (0.072, 0.339)	0.125 (0.078, 0.288)
++–	graduation	206	0	319	182	169
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	5 (2, 12)	13 (8, 18)	3 (0, 12)	5 (2, 12)	4 (1, 11)
	n_unique	4 (2, 11)	12 (7, 17)	3 (0, 12)	5 (2, 11)	4 (1, 10)
	post_p	0.3 (0.13, 0.6)	NA (NA, NA)	0.83 (0.46, 0.98)	0.3 (0.13, 0.62)	0.35 (0.15, 0.64)
	rate	0.139 (0.078, 0.371)	0.078 (0.045, 0.128)	0.036 (0.011, 0.113)	0.135 (0.075, 0.371)	0.131 (0.067, 0.409)
++-+	graduation	286	0	370	298	276
	futility	0	0	0	0	0
	max_n	0	0	0	1	0
	n	5 (2, 13)	12 (8, 18)	2 (0, 10)	5 (2, 12)	4 (1, 11)
	n_unique	5 (2, 12)	12 (7, 17)	2 (0, 9)	5 (2, 11)	4 (1, 10)
	post_p	0.29 (0.11, 0.61)	NA (NA, NA)	0.8 (0.44, 0.96)	0.3 (0.13, 0.61)	0.34 (0.16, 0.63)
	rate	0.128 (0.076, 0.367)	0.074 (0.044, 0.12)	0.04 (0.009, 0.108)	0.134 (0.076, 0.352)	0.133 (0.072, 0.401)
+++-	graduation	294	0	392	276	296
	futility	0	0	0	0	0
	max_n	27	0	70	18	12
	n	5 (2, 12)	12 (7, 18)	2 (0, 10)	5 (2, 13)	4 (1, 10)
	n_unique	5 (2, 11)	12 (6, 17)	2 (0, 9)	4 (2, 11)	3 (1, 10)
	post_p	0.33 (0.14, 0.61)	NA (NA, NA)	0.77 (0.42, 0.96)	0.3 (0.14, 0.61)	0.33 (0.16, 0.62)
	rate	0.129 (0.073, 0.32)	0.072 (0.044, 0.12)	0.039 (0.01, 0.112)	0.133 (0.073, 0.41)	0.133 (0.069, 0.512)
++++	graduation	343	0	415	346	352
	futility	0	0	0	0	0
	max_n	26	0	67	17	12
	n	5 (2, 12)	12 (7, 18)	2 (0, 8)	5 (2, 12)	4 (1, 11)
	n_unique	5 (1, 12)	12 (7, 17)	2 (0, 8)	5 (2, 12)	3 (1, 10)
	post_p	0.33 (0.13, 0.62)	NA (NA, NA)	0.78 (0.41, 0.95)	0.32 (0.14, 0.62)	0.34 (0.15, 0.63)
	rate	0.127 (0.075, 0.378)	0.072 (0.045, 0.121)	0.042 (0, 0.122)	0.128 (0.073, 0.318)	0.133 (0.068, 0.458)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	272
	time_stop	10 (4, 30)
	n_trt	70 (30, 204)
	n_control	110 (46, 360)
	post_p	1 (0.93, 1)
	order	2 (1, 3)
TP53- & AR-	count	366	2	1	1
	time_stop	9 (6, 26)	10 (9, 12)	12 (12, 12)	13 (13, 13)
	n_trt	33 (26, 106)	29 (29, 29)	30 (30, 30)	26 (26, 26)
	n_control	41 (27, 118)	35 (34, 36)	57 (57, 57)	59 (59, 59)
	post_p	0.96 (0.88, 1)	0.94 (0.9, 0.97)	0.9 (0.9, 0.9)	0.88 (0.88, 0.88)
	order	1 (1, 2)	2 (2, 2)	3 (3, 3)	2 (2, 2)
TP53+	count	235			1
	time_stop	13 (9, 32)			9 (9, 9)
	n_trt	43 (27, 126)			25 (25, 25)
	n_control	64 (36, 174)			37 (37, 37)
	post_p	1 (0.94, 1)			0.96 (0.96, 0.96)
	order	2 (1, 4)			1 (1, 1)
DRD+	count	100	1
	time_stop	24 (17, 33)	19 (19, 19)
	n_trt	30 (25, 51)	28 (28, 28)
	n_control	74 (47, 110)	48 (48, 48)
	post_p	0.99 (0.95, 1)	0.98 (0.98, 0.98)
	order	3 (1.9, 5)	3 (3, 3)
TEfus+	count	161			2
	time_stop	19 (11, 33)			13 (11, 15)
	n_trt	38 (26, 83)			30 (27, 33)
	n_control	74 (42, 144)			48 (38, 58)
	post_p	1 (0.96, 1)			0.9 (0.87, 0.93)
	order	3 (2, 5)			1.5 (1.1, 1.9)

Futility:

signature	var	Taxel_therapies	Carboplatin	Niraparib	Hormone_therapies
all	count	96	70	77
	time_stop	28 (17, 35)	30 (20, 35)	30 (20, 35)
	n_trt	102 (70, 169)	110 (74, 175)	111 (76, 186)
	n_control	334 (190, 418)	348 (238, 435)	346 (247, 436)
	post_p	0 (0, 0)	0 (0, 0)	0 (0, 0)
	order	6 (2, 9)	6 (3, 10)	6 (3, 10)
TP53- & AR-	count	383	396	402	1
	time_stop	21 (13, 31)	20 (13, 31)	19 (13, 32)	6 (6, 6)
	n_trt	35 (25, 92)	37 (25, 102)	36 (25, 85)	26 (26, 26)
	n_control	104 (60, 166)	101 (58, 162)	97 (57, 165)	26 (26, 26)
	post_p	0.04 (0, 0.18)	0.05 (0, 0.21)	0.06 (0, 0.2)	0.27 (0.27, 0.27)
	order	3 (1, 6)	3 (1, 6)	3 (1, 6)	1 (1, 1)
TP53+	count	263	231	225
	time_stop	24 (12, 33)	26 (14, 34)	24 (14, 34)
	n_trt	49 (27, 97)	54 (27, 105)	48 (28, 100)
	n_control	122 (53, 191)	140 (70, 191)	129 (64, 193)
	post_p	0.01 (0, 0.07)	0.01 (0, 0.07)	0.01 (0, 0.06)
	order	4 (1, 8)	5 (1, 8)	3 (1, 8)
DRD+	count	137	199	182
	time_stop	27 (20, 34)	25 (17, 34)	26 (16, 34)
	n_trt	34 (26, 56)	42 (28, 65)	40 (27, 64)
	n_control	86 (59, 114)	81 (50, 113)	80 (47, 111)
	post_p	0.01 (0, 0.06)	0.01 (0, 0.05)	0.01 (0, 0.06)
	order	6 (3, 9)	5 (2, 8.2)	5 (2, 8)
TEfus+	count	224	203	231
	time_stop	23 (15, 33)	26 (15, 33)	26 (16, 34)
	n_trt	45 (27, 81)	47 (29, 80)	45 (27, 78)
	n_control	102 (55, 149)	111 (56, 150)	113 (63, 153)
	post_p	0.01 (0, 0.07)	0.01 (0, 0.06)	0.01 (0, 0.05)
	order	4 (1, 9)	5 (2, 9)	5 (2, 8)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	272	272	272	272	272	272	272	272	272	272	272	272	272	272	272	272
		time	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)	10 (4, 30)
		n	22 (13, 55)	3 (1, 8)	13 (5, 43)	6 (1, 24)	1 (0, 5)	1 (0, 5)	1 (0, 6)	1 (0, 5)	4 (0, 14)	2 (0, 9)	2 (0, 8)	2 (0, 8)	1 (0, 7)	1 (0, 6)	1 (0, 6)	1 (0, 5)
		post_p	0.91 (0.64, 1)	0.7 (0.53, 0.9)	0.84 (0.6, 1)	0.72 (0.53, 0.98)	0.62 (0.52, 0.9)	0.64 (0.51, 0.88)	0.62 (0.52, 0.91)	0.68 (0.52, 0.89)	0.66 (0.52, 0.91)	0.62 (0.52, 0.93)	0.65 (0.52, 0.92)	0.64 (0.53, 0.91)	0.62 (0.52, 0.93)	0.63 (0.52, 0.91)	0.66 (0.52, 0.88)	0.64 (0.53, 0.88)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.036 (0, 0.057)	0.01 (0, 0.073)	0.033 (0, 0.058)	0.024 (0, 0.066)	0 (0, 0.07)	0 (0, 0.076)	0 (0, 0.071)	0 (0, 0.072)	0.013 (0, 0.074)	0 (0, 0.072)	0 (0, 0.078)	0 (0, 0.064)	0 (0, 0.075)	0 (0, 0.079)	0.014 (0, 0.078)	0 (0, 0.07)
DRD+		count					100	100	100	100					100	100	100	100
		time					24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)					24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)
		n					3 (1, 11)	3 (0, 12)	4 (1, 9)	3 (0, 8)					4 (1, 10)	4 (2, 9)	3 (1, 10)	3 (0, 8)
		post_p					0.76 (0.62, 0.94)	0.78 (0.59, 0.92)	0.73 (0.55, 0.94)	0.71 (0.53, 0.9)					0.72 (0.54, 0.94)	0.75 (0.53, 0.91)	0.74 (0.53, 0.94)	0.74 (0.54, 0.88)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.026 (0, 0.063)	0.033 (0, 0.06)	0.032 (0, 0.072)	0.029 (0, 0.079)					0.03 (0, 0.07)	0.029 (0, 0.072)	0.029 (0, 0.07)	0.031 (0, 0.071)
	Taxel_therapies	count					1	1	1	1					1	1	1	1
		time					19 (19, 19)	19 (19, 19)	19 (19, 19)	19 (19, 19)					19 (19, 19)	19 (19, 19)	19 (19, 19)	19 (19, 19)
		n					2 (2, 2)	5 (5, 5)	5 (5, 5)	4 (4, 4)					3 (3, 3)	0 (0, 0)	5 (5, 5)	4 (4, 4)
		post_p					0.52 (0.52, 0.52)	0.74 (0.74, 0.74)	0.84 (0.84, 0.84)	0.68 (0.68, 0.68)					0.62 (0.62, 0.62)	NA (NA, NA)	0.76 (0.76, 0.76)	0.64 (0.64, 0.64)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.082 (0.082, 0.082)	0.087 (0.087, 0.087)	0.026 (0.026, 0.026)	0 (0, 0)					0.056 (0.056, 0.056)	NA (NA, NA)	0.024 (0.024, 0.024)	0.033 (0.033, 0.033)
TEfus+	Hormone_therapies	count		161		161		161		161		161		161		161		161
		time		19 (11, 33)		19 (11, 33)		19 (11, 33)		19 (11, 33)		19 (11, 33)		19 (11, 33)		19 (11, 33)		19 (11, 33)
		n		5 (2, 11)		13 (6, 32)		2 (0, 7)		2 (0, 7)		5 (1, 13)		4 (2, 12)		3 (0, 8)		3 (0, 6)
		post_p		0.8 (0.56, 0.95)		0.88 (0.71, 0.99)		0.72 (0.55, 0.9)		0.73 (0.52, 0.88)		0.72 (0.52, 0.94)		0.77 (0.55, 0.94)		0.71 (0.54, 0.91)		0.69 (0.53, 0.87)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.031 (0, 0.071)		0.035 (0.008, 0.06)		0.03 (0, 0.073)		0.019 (0, 0.062)		0.035 (0, 0.074)		0.028 (0, 0.063)		0.019 (0, 0.078)		0.025 (0, 0.07)
	Niraparib	count		2		2		2		2		2		2		2		2
		time		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)		13 (11, 15)
		n		4 (2, 5)		5 (3, 7)		8 (6, 10)		2 (1, 4)		2 (2, 3)		2 (1, 2)		2 (2, 3)		4 (4, 5)
		post_p		0.56 (0.54, 0.57)		0.67 (0.54, 0.79)		0.84 (0.78, 0.9)		0.52 (0.52, 0.52)		0.54 (0.52, 0.57)		0.56 (0.52, 0.59)		0.54 (0.52, 0.57)		0.59 (0.55, 0.63)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.109 (0.062, 0.157)		0 (0, 0)		0.025 (0.005, 0.046)		0.041 (0.041, 0.041)		0.028 (0.006, 0.051)		0.035 (0.007, 0.062)		0.085 (0.082, 0.089)		0.054 (0.05, 0.058)
TP53- & AR-	Carboplatin	count	1	1			1	1
		time	12 (12, 12)	12 (12, 12)			12 (12, 12)	12 (12, 12)
		n	14 (14, 14)	3 (3, 3)			3 (3, 3)	10 (10, 10)
		post_p	0.71 (0.71, 0.71)	0.62 (0.62, 0.62)			0.56 (0.56, 0.56)	0.8 (0.8, 0.8)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.029 (0.029, 0.029)	0 (0, 0)			0.063 (0.063, 0.063)	0.032 (0.032, 0.032)
	Hormone_therapies	count	366	366			366	366
		time	9 (6, 26)	9 (6, 26)			9 (6, 26)	9 (6, 26)
		n	26 (20, 74)	4 (2, 11)			2 (0, 9)	2 (0, 6)
		post_p	0.9 (0.75, 1)	0.71 (0.54, 0.87)			0.61 (0.52, 0.85)	0.61 (0.51, 0.83)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.035 (0.016, 0.055)	0.024 (0, 0.074)			0 (0, 0.062)	0 (0, 0.072)
	Niraparib	count	1	1			1	1
		time	13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)
		n	10 (10, 10)	3 (3, 3)			4 (4, 4)	9 (9, 9)
		post_p	0.72 (0.72, 0.72)	0.56 (0.56, 0.56)			0.56 (0.56, 0.56)	0.84 (0.84, 0.84)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.041 (0.041, 0.041)	0 (0, 0)			0.08 (0.08, 0.08)	0.036 (0.036, 0.036)
	Taxel_therapies	count	2	2			2	2
		time	10 (9, 12)	10 (9, 12)			10 (9, 12)	10 (9, 12)
		n	20 (18, 21)	4 (4, 5)			2 (2, 2)	3 (2, 4)
		post_p	0.79 (0.72, 0.86)	0.65 (0.61, 0.69)			0.6 (0.52, 0.68)	0.74 (0.74, 0.74)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.038 (0.024, 0.052)	0.067 (0.055, 0.08)			0.044 (0.009, 0.079)	0 (0, 0)
TP53+	Hormone_therapies	count			235	235			235	235			235	235			235	235
		time			13 (9, 32)	13 (9, 32)			13 (9, 32)	13 (9, 32)			13 (9, 32)	13 (9, 32)			13 (9, 32)	13 (9, 32)
		n			20 (12, 53)	10 (4, 28)			2 (0, 6)	2 (0, 6)			3 (0, 10)	3 (1, 11)			2 (0, 6)	2 (0, 6)
		post_p			0.91 (0.75, 1)	0.83 (0.61, 0.99)			0.62 (0.52, 0.87)	0.66 (0.52, 0.87)			0.7 (0.52, 0.93)	0.72 (0.53, 0.91)			0.65 (0.52, 0.9)	0.63 (0.53, 0.87)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.035 (0.013, 0.056)	0.033 (0, 0.063)			0 (0, 0.075)	0 (0, 0.071)			0.02 (0, 0.078)	0.018 (0, 0.064)			0 (0, 0.065)	0 (0, 0.078)
	Niraparib	count			1	1			1	1			1	1			1	1
		time			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)
		n			5 (5, 5)	4 (4, 4)			4 (4, 4)	4 (4, 4)			4 (4, 4)	2 (2, 2)			0 (0, 0)	2 (2, 2)
		post_p			0.74 (0.74, 0.74)	0.64 (0.64, 0.64)			0.65 (0.65, 0.65)	0.74 (0.74, 0.74)			0.61 (0.61, 0.61)	0.57 (0.57, 0.57)			NA (NA, NA)	0.63 (0.63, 0.63)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0 (0, 0)	0 (0, 0)			0.053 (0.053, 0.053)	0 (0, 0)			0 (0, 0)	0 (0, 0)			NA (NA, NA)	0 (0, 0)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	70	70	70	70	70	70	70	70	70	70	70	70	70	70	70	70
		time	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)
		n	18 (8, 51)	4 (2, 13)	11 (5, 43)	8 (3, 22)	6 (2, 15)	6 (2, 15)	4 (1, 9)	3 (1, 8)	4 (2, 10)	3 (1, 8)	4 (1, 12)	4 (1, 10)	4 (1, 8)	4 (1, 8)	4 (1, 10)	4 (1, 10)
		post_p	0.11 (0.02, 0.34)	0.29 (0.13, 0.45)	0.21 (0.06, 0.36)	0.24 (0.06, 0.4)	0.31 (0.12, 0.45)	0.31 (0.09, 0.46)	0.3 (0.18, 0.44)	0.31 (0.17, 0.42)	0.27 (0.11, 0.42)	0.32 (0.18, 0.45)	0.31 (0.11, 0.46)	0.28 (0.14, 0.43)	0.33 (0.17, 0.48)	0.3 (0.09, 0.47)	0.29 (0.18, 0.45)	0.32 (0.1, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.117 (0.086, 0.16)	0.149 (0.082, 0.51)	0.122 (0.09, 0.194)	0.126 (0.089, 0.374)	0.133 (0.087, 0.554)	0.135 (0.089, 0.311)	0.149 (0.093, 0.314)	0.178 (0.094, 0.456)	0.146 (0.102, 0.476)	0.14 (0.084, 0.452)	0.136 (0.084, 0.336)	0.168 (0.099, 0.608)	0.142 (0.097, 0.634)	0.144 (0.095, 0.492)	0.134 (0.084, 0.479)	0.144 (0.09, 0.5)
	Niraparib	count	77	77	77	77	77	77	77	77	77	77	77	77	77	77	77	77
		time	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)
		n	20 (8, 57)	5 (1, 13)	11 (4, 40)	7 (4, 21)	6 (3, 12)	6 (3, 14)	4 (2, 9)	4 (1, 8)	5 (2, 12)	4 (1, 8)	4 (1, 12)	3 (1, 8)	4 (1, 8)	3 (1, 8)	4 (2, 8)	4 (2, 7)
		post_p	0.1 (0.01, 0.29)	0.32 (0.14, 0.47)	0.17 (0.06, 0.4)	0.24 (0.1, 0.45)	0.31 (0.13, 0.47)	0.24 (0.12, 0.44)	0.31 (0.16, 0.47)	0.29 (0.13, 0.44)	0.29 (0.12, 0.47)	0.29 (0.16, 0.47)	0.32 (0.14, 0.44)	0.32 (0.11, 0.45)	0.31 (0.14, 0.46)	0.3 (0.17, 0.48)	0.32 (0.17, 0.46)	0.3 (0.16, 0.43)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.119 (0.094, 0.172)	0.123 (0.082, 0.604)	0.118 (0.086, 0.266)	0.117 (0.076, 0.255)	0.125 (0.087, 0.215)	0.143 (0.087, 0.311)	0.139 (0.09, 0.405)	0.148 (0.095, 0.453)	0.134 (0.081, 0.374)	0.16 (0.09, 0.658)	0.152 (0.089, 0.354)	0.145 (0.09, 0.527)	0.162 (0.098, 0.393)	0.179 (0.104, 0.438)	0.127 (0.085, 0.342)	0.145 (0.094, 0.455)
	Taxel_therapies	count	96	96	96	96	96	96	96	96	96	96	96	96	96	96	96	96
		time	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)	28 (17, 35)
		n	16 (6, 36)	6 (2, 12)	11 (5, 27)	10 (5, 28)	4 (1, 11)	4 (0, 12)	3 (0, 8)	2 (0, 6)	6 (3, 16)	5 (2, 10)	6 (2, 12)	5 (2, 10)	3 (1, 7)	3 (1, 7)	3 (0, 8)	2 (0, 6)
		post_p	0.12 (0.02, 0.33)	0.25 (0.12, 0.45)	0.19 (0.07, 0.44)	0.19 (0.04, 0.42)	0.27 (0.15, 0.47)	0.28 (0.1, 0.45)	0.32 (0.18, 0.48)	0.3 (0.17, 0.46)	0.29 (0.09, 0.45)	0.28 (0.13, 0.44)	0.27 (0.13, 0.46)	0.27 (0.14, 0.45)	0.35 (0.17, 0.45)	0.32 (0.17, 0.46)	0.33 (0.14, 0.46)	0.34 (0.2, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.122 (0.085, 0.213)	0.135 (0.083, 0.3)	0.122 (0.091, 0.198)	0.124 (0.089, 0.199)	0.156 (0.085, 0.456)	0.164 (0.09, 0.366)	0.148 (0.081, 0.358)	0.157 (0.095, 0.7)	0.137 (0.087, 0.275)	0.141 (0.082, 0.341)	0.13 (0.083, 0.267)	0.141 (0.088, 0.318)	0.157 (0.09, 0.453)	0.165 (0.084, 0.562)	0.155 (0.081, 0.487)	0.145 (0.083, 0.482)
DRD+	Carboplatin	count					199	199	199	199					199	199	199	199
		time					25 (17, 34)	25 (17, 34)	25 (17, 34)	25 (17, 34)					25 (17, 34)	25 (17, 34)	25 (17, 34)	25 (17, 34)
		n					6 (2, 15)	6 (2, 15)	5 (2, 10)	4 (1, 9)					4 (1, 9)	4 (1, 10)	4 (1, 9)	4 (2, 10)
		post_p					0.32 (0.12, 0.47)	0.27 (0.11, 0.47)	0.33 (0.16, 0.47)	0.34 (0.15, 0.46)					0.33 (0.15, 0.47)	0.35 (0.13, 0.47)	0.34 (0.16, 0.47)	0.32 (0.14, 0.48)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.122 (0.083, 0.327)	0.134 (0.088, 0.311)	0.141 (0.093, 0.351)	0.157 (0.085, 0.388)					0.14 (0.087, 0.452)	0.134 (0.084, 0.398)	0.138 (0.08, 0.431)	0.144 (0.087, 0.43)
	Niraparib	count					182	182	182	182					182	182	182	182
		time					26 (16, 34)	26 (16, 34)	26 (16, 34)	26 (16, 34)					26 (16, 34)	26 (16, 34)	26 (16, 34)	26 (16, 34)
		n					7 (3, 15)	6 (3, 14)	4 (2, 10)	4 (1, 10)					4 (1, 9)	4 (1, 10)	4 (1, 10)	4 (2, 9)
		post_p					0.3 (0.11, 0.47)	0.31 (0.12, 0.45)	0.31 (0.16, 0.46)	0.3 (0.18, 0.48)					0.31 (0.15, 0.47)	0.32 (0.15, 0.48)	0.34 (0.16, 0.45)	0.34 (0.17, 0.47)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.129 (0.085, 0.244)	0.127 (0.09, 0.281)	0.146 (0.089, 0.404)	0.143 (0.083, 0.461)					0.158 (0.097, 0.394)	0.153 (0.088, 0.378)	0.145 (0.085, 0.454)	0.145 (0.085, 0.362)
	Taxel_therapies	count					137	137	137	137					137	137	137	137
		time					27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)					27 (20, 34)	27 (20, 34)	27 (20, 34)	27 (20, 34)
		n					5 (2, 13)	5 (2, 13)	3 (1, 9)	3 (1, 7)					3 (1, 8)	3 (1, 9)	4 (1, 9)	3 (1, 8)
		post_p					0.3 (0.12, 0.47)	0.3 (0.12, 0.46)	0.33 (0.18, 0.48)	0.35 (0.19, 0.48)					0.36 (0.17, 0.46)	0.32 (0.18, 0.46)	0.34 (0.18, 0.46)	0.34 (0.19, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.151 (0.083, 0.4)	0.142 (0.081, 0.383)	0.149 (0.083, 0.48)	0.139 (0.087, 0.516)					0.15 (0.091, 0.395)	0.154 (0.087, 0.444)	0.141 (0.087, 0.649)	0.15 (0.081, 0.468)
TEfus+	Carboplatin	count		203		203		203		203		203		203		203		203
		time		26 (15, 33)		26 (15, 33)		26 (15, 33)		26 (15, 33)		26 (15, 33)		26 (15, 33)		26 (15, 33)		26 (15, 33)
		n		5 (2, 13)		9 (3, 25)		6 (2, 15)		4 (1, 9)		4 (1, 11)		4 (1, 13)		4 (2, 10)		4 (2, 10)
		post_p		0.32 (0.14, 0.47)		0.24 (0.07, 0.43)		0.3 (0.09, 0.46)		0.31 (0.14, 0.45)		0.31 (0.17, 0.47)		0.33 (0.15, 0.47)		0.32 (0.13, 0.47)		0.33 (0.14, 0.46)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.132 (0.078, 0.358)		0.121 (0.088, 0.291)		0.131 (0.086, 0.307)		0.152 (0.082, 0.496)		0.138 (0.08, 0.423)		0.137 (0.087, 0.397)		0.136 (0.087, 0.443)		0.135 (0.085, 0.433)
	Niraparib	count		231		231		231		231		231		231		231		231
		time		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)
		n		4 (2, 13)		9 (3, 25)		7 (3, 15)		4 (1, 9)		4 (1, 9)		4 (1, 10)		4 (1, 10)		4 (2, 10)
		post_p		0.33 (0.12, 0.47)		0.23 (0.09, 0.45)		0.3 (0.12, 0.46)		0.33 (0.14, 0.47)		0.33 (0.15, 0.47)		0.34 (0.15, 0.46)		0.31 (0.15, 0.47)		0.32 (0.16, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.133 (0.084, 0.419)		0.121 (0.085, 0.29)		0.134 (0.087, 0.298)		0.145 (0.086, 0.45)		0.147 (0.083, 0.594)		0.14 (0.084, 0.386)		0.14 (0.081, 0.408)		0.139 (0.087, 0.339)
	Taxel_therapies	count		224		224		224		224		224		224		224		224
		time		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)		23 (15, 33)
		n		5 (2, 12)		11 (6, 29)		4 (1, 13)		3 (1, 7)		5 (2, 12)		5 (2, 11)		3 (1, 8)		3 (1, 7)
		post_p		0.29 (0.12, 0.45)		0.2 (0.04, 0.45)		0.33 (0.13, 0.46)		0.34 (0.19, 0.46)		0.3 (0.13, 0.46)		0.32 (0.13, 0.47)		0.35 (0.17, 0.46)		0.35 (0.17, 0.48)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.138 (0.087, 0.341)		0.123 (0.089, 0.201)		0.144 (0.081, 0.446)		0.148 (0.085, 0.577)		0.138 (0.086, 0.354)		0.132 (0.086, 0.3)		0.154 (0.082, 0.487)		0.155 (0.082, 0.544)
TP53- & AR-	Carboplatin	count	396	396			396	396
		time	20 (13, 31)	20 (13, 31)			20 (13, 31)	20 (13, 31)
		n	20 (8, 66)	5 (2, 13)			7 (3, 15)	6 (2, 15)
		post_p	0.18 (0.02, 0.44)	0.34 (0.16, 0.48)			0.34 (0.15, 0.48)	0.33 (0.11, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.114 (0.085, 0.182)	0.129 (0.075, 0.345)			0.121 (0.082, 0.33)	0.135 (0.081, 0.326)
	Hormone_therapies	count	1	1			1	1
		time	6 (6, 6)	6 (6, 6)			6 (6, 6)	6 (6, 6)
		n	22 (22, 22)	3 (3, 3)			1 (1, 1)	0 (0, 0)
		post_p	0.36 (0.36, 0.36)	0.16 (0.16, 0.16)			0.44 (0.44, 0.44)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.078 (0.078, 0.078)	0.284 (0.284, 0.284)			0 (0, 0)	NA (NA, NA)
	Niraparib	count	402	402			402	402
		time	19 (13, 32)	19 (13, 32)			19 (13, 32)	19 (13, 32)
		n	18 (8, 55)	5 (2, 13)			7 (3, 15)	6 (3, 13)
		post_p	0.21 (0.03, 0.43)	0.35 (0.16, 0.48)			0.34 (0.13, 0.48)	0.32 (0.12, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.109 (0.083, 0.194)	0.124 (0.077, 0.464)			0.125 (0.085, 0.279)	0.129 (0.085, 0.314)
	Taxel_therapies	count	383	383			383	383
		time	21 (13, 31)	21 (13, 31)			21 (13, 31)	21 (13, 31)
		n	19 (10, 55)	6 (2, 15)			5 (2, 14)	5 (2, 14)
		post_p	0.16 (0.02, 0.43)	0.33 (0.13, 0.47)			0.32 (0.15, 0.47)	0.36 (0.16, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.117 (0.086, 0.18)	0.123 (0.08, 0.299)			0.145 (0.083, 0.429)	0.132 (0.078, 0.422)
TP53+	Carboplatin	count			231	231			231	231			231	231			231	231
		time			26 (14, 34)	26 (14, 34)			26 (14, 34)	26 (14, 34)			26 (14, 34)	26 (14, 34)			26 (14, 34)	26 (14, 34)
		n			12 (5, 40)	9 (3, 27)			4 (1, 10)	4 (1, 10)			4 (1, 13)	4 (1, 13)			4 (1, 9)	4 (2, 10)
		post_p			0.19 (0.03, 0.43)	0.23 (0.06, 0.45)			0.32 (0.16, 0.46)	0.33 (0.17, 0.47)			0.33 (0.16, 0.47)	0.33 (0.14, 0.47)			0.34 (0.17, 0.47)	0.33 (0.16, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.122 (0.086, 0.23)	0.129 (0.087, 0.298)			0.141 (0.085, 0.366)	0.149 (0.08, 0.465)			0.136 (0.085, 0.43)	0.133 (0.082, 0.413)			0.139 (0.085, 0.415)	0.134 (0.078, 0.425)
	Niraparib	count			225	225			225	225			225	225			225	225
		time			24 (14, 34)	24 (14, 34)			24 (14, 34)	24 (14, 34)			24 (14, 34)	24 (14, 34)			24 (14, 34)	24 (14, 34)
		n			11 (5, 40)	8 (3, 24)			4 (2, 10)	4 (1, 9)			4 (1, 11)	4 (1, 11)			4 (1, 9)	4 (2, 9)
		post_p			0.22 (0.05, 0.44)	0.23 (0.08, 0.46)			0.34 (0.16, 0.48)	0.32 (0.16, 0.47)			0.35 (0.17, 0.48)	0.34 (0.15, 0.47)			0.33 (0.15, 0.47)	0.33 (0.18, 0.47)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.115 (0.084, 0.239)	0.121 (0.086, 0.288)			0.137 (0.079, 0.383)	0.146 (0.081, 0.461)			0.138 (0.076, 0.357)	0.138 (0.079, 0.381)			0.143 (0.082, 0.454)	0.138 (0.085, 0.374)
	Taxel_therapies	count			263	263			263	263			263	263			263	263
		time			24 (12, 33)	24 (12, 33)			24 (12, 33)	24 (12, 33)			24 (12, 33)	24 (12, 33)			24 (12, 33)	24 (12, 33)
		n			12 (5, 33)	11 (6, 27)			3 (1, 8)	3 (1, 8)			5 (2, 14)	5 (2, 11)			3 (1, 8)	3 (0, 8)
		post_p			0.19 (0.05, 0.43)	0.19 (0.04, 0.43)			0.35 (0.18, 0.48)	0.37 (0.21, 0.48)			0.3 (0.13, 0.46)	0.32 (0.14, 0.48)			0.35 (0.18, 0.48)	0.35 (0.18, 0.47)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.121 (0.083, 0.217)	0.124 (0.086, 0.216)			0.157 (0.077, 0.491)	0.143 (0.082, 0.526)			0.134 (0.084, 0.345)	0.135 (0.085, 0.296)			0.149 (0.071, 0.769)	0.155 (0.084, 0.602)