Setting description

Hormone_therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 272 0 0 0
TP53- & AR- 366 2 1 1
TP53+ 235 0 0 1
DRD+ 100 1 0 0
TEfus+ 161 0 0 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.544 0.000 0.000 0.000
TP53- & AR- 0.732 0.004 0.002 0.002
TP53+ 0.470 0.000 0.000 0.002
DRD+ 0.200 0.002 0.000 0.000
TEfus+ 0.322 0.000 0.000 0.004
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 96 70 77
TP53- & AR- 1 383 396 402
TP53+ 0 263 231 225
DRD+ 0 137 199 182
TEfus+ 0 224 203 231
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.192 0.140 0.154
TP53- & AR- 0.002 0.766 0.792 0.804
TP53+ 0.000 0.526 0.462 0.450
DRD+ 0.000 0.274 0.398 0.364
TEfus+ 0.000 0.448 0.406 0.462
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 18 16 24 10
TP53+ 72 12 27 19
DRD+ 0 0 0 0
TEfus+ 0 0 0 1
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.036 0.032 0.048 0.020
TP53+ 0.144 0.024 0.054 0.038
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.002


Errors & power

The overall error was 0.448.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.442             0.006             0.002             0.008 

The overall power was 0.544.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.544             0.000             0.000             0.000 

Median results at the end of the trial

By signature:
signature var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
all graduation 0 0 272 0 0
futility 70 0 0 77 96
max_n 0 0 0 0 0
n 154 (97, 249) 434 (366, 478) 132 (34, 264) 156 (94, 231) 148 (93, 236)
n_unique 144 (90, 236) 408 (343, 449) 125 (32, 249) 145 (88, 215) 137 (86, 225)
time_trial 36 (33, 36) 36 (36, 36) 32 (5, 36) 36 (32, 36) 36 (29, 36)
time_stop 30 (20, 35) NA (NA, NA) 10 (4, 30) 30 (20, 35) 28 (17, 35)
post_p 0 (0, 0) NA (NA, NA) 1 (1, 1) 0 (0, 0) 0 (0, 0)
rate 0.114 (0.101, 0.13) 0.073 (0.067, 0.079) 0.038 (0.032, 0.045) 0.113 (0.101, 0.127) 0.114 (0.102, 0.129)
DRD+ graduation 0 0 100 0 1
futility 199 0 0 182 137
max_n 0 0 0 0 0
n 53 (31, 81) 113 (91, 134) 26 (2, 56) 53 (32, 79) 42 (25, 71)
n_unique 48 (29, 75) 105 (86, 125) 24 (1, 53) 50 (30, 74) 39 (22, 67)
time_trial 36 (21, 36) 36 (36, 36) 36 (24, 36) 36 (21, 36) 36 (26, 36)
time_stop 25 (17, 34) NA (NA, NA) 24 (17, 33) 26 (16, 34) 27 (20, 34)
post_p 0.02 (0, 0.14) NA (NA, NA) 0.99 (0.77, 1) 0.01 (0, 0.14) 0.03 (0, 0.19)
rate 0.115 (0.097, 0.142) 0.073 (0.062, 0.085) 0.037 (0.024, 0.054) 0.116 (0.097, 0.142) 0.115 (0.093, 0.151)
TEfus+ graduation 0 0 161 2 0
futility 203 0 0 231 224
max_n 0 0 0 1 0
n 63 (33, 104) 154 (131, 179) 38 (8, 95) 60 (30, 98) 59 (32, 104)
n_unique 58 (31, 95) 144 (121, 167) 35 (7, 89) 56 (29, 91) 55 (29, 97)
time_trial 36 (21, 36) 36 (36, 36) 36 (15, 36) 36 (20, 36) 36 (17, 36)
time_stop 26 (15, 33) NA (NA, NA) 19 (11, 33) 26 (16, 34) 23 (15, 33)
post_p 0.01 (0, 0.11) NA (NA, NA) 1 (0.92, 1) 0.01 (0, 0.09) 0.01 (0, 0.1)
rate 0.114 (0.096, 0.142) 0.072 (0.064, 0.082) 0.039 (0.028, 0.049) 0.115 (0.095, 0.142) 0.114 (0.095, 0.141)
TP53- & AR- graduation 1 0 366 1 2
futility 396 0 1 402 383
max_n 24 0 18 10 16
n 44 (25, 124) 173 (107, 204) 32 (19, 132) 42 (25, 115) 39 (25, 120)
n_unique 42 (23, 121) 162 (97, 192) 30 (18, 125) 39 (24, 109) 35 (23, 114)
time_trial 23 (13, 36) 36 (36, 36) 12 (7, 36) 22 (13, 36) 23 (14, 36)
time_stop 20 (13, 31) NA (NA, NA) 9 (6, 25) 19 (13, 32) 21 (13, 31)
post_p 0.01 (0, 0.1) NA (NA, NA) 1 (0.95, 1) 0.01 (0, 0.11) 0.01 (0, 0.09)
rate 0.116 (0.096, 0.147) 0.072 (0.063, 0.083) 0.039 (0.03, 0.05) 0.115 (0.095, 0.146) 0.117 (0.098, 0.149)
TP53+ graduation 0 0 235 1 0
futility 231 0 0 225 263
max_n 27 0 72 19 12
n 70 (34, 135) 202 (177, 225) 48 (13, 152) 70 (33, 134) 67 (32, 129)
n_unique 64 (31, 130) 189 (165, 210) 45 (12, 142) 65 (31, 124) 62 (31, 120)
time_trial 36 (19, 36) 36 (36, 36) 36 (10, 36) 36 (17, 36) 35 (15, 36)
time_stop 26 (14, 34) NA (NA, NA) 13 (9, 32) 24 (14, 34) 24 (12, 33)
post_p 0 (0, 0.07) NA (NA, NA) 1 (0.97, 1) 0.01 (0, 0.07) 0 (0, 0.07)
rate 0.115 (0.097, 0.14) 0.073 (0.064, 0.082) 0.038 (0.029, 0.047) 0.113 (0.097, 0.137) 0.115 (0.096, 0.141)


By subgroup combinations:
subtype var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
—- graduation 404 0 465 407 401
futility 0 0 0 0 0
max_n 24 0 18 10 16
n 23 (8, 80) 111 (69, 134) 25 (15, 100) 20 (8, 74) 21 (9, 77)
n_unique 21 (8, 77) 104 (62, 127) 24 (15, 95) 19 (7, 73) 19 (8, 74)
post_p 0.06 (0, 0.27) NA (NA, NA) 1 (0.88, 1) 0.07 (0.01, 0.3) 0.06 (0, 0.23)
rate 0.118 (0.091, 0.166) 0.072 (0.061, 0.085) 0.039 (0.029, 0.054) 0.117 (0.089, 0.174) 0.119 (0.094, 0.181)
—+ graduation 418 0 472 432 423
futility 0 0 0 0 0
max_n 23 0 18 11 16
n 6 (2, 18) 19 (10, 28) 4 (1, 13) 6 (2, 15) 7 (2, 18)
n_unique 5 (2, 17) 17 (9, 26) 4 (1, 11) 5 (2, 15) 6 (2, 17)
post_p 0.29 (0.12, 0.61) NA (NA, NA) 0.85 (0.51, 0.98) 0.29 (0.12, 0.57) 0.27 (0.1, 0.53)
rate 0.123 (0.072, 0.319) 0.073 (0.049, 0.105) 0.037 (0.013, 0.086) 0.122 (0.073, 0.371) 0.121 (0.082, 0.272)
–+- graduation 234 0 371 228 269
futility 0 0 0 0 0
max_n 27 0 70 19 12
n 16 (5, 53) 71 (57, 83) 22 (7, 68) 15 (5, 52) 14 (5, 52)
n_unique 14 (5, 50) 67 (54, 78) 21 (7, 64) 14 (5, 50) 13 (5, 49)
post_p 0.12 (0.02, 0.36) NA (NA, NA) 0.99 (0.83, 1) 0.14 (0.02, 0.38) 0.12 (0.03, 0.37)
rate 0.121 (0.089, 0.223) 0.074 (0.06, 0.09) 0.038 (0.026, 0.053) 0.118 (0.086, 0.21) 0.12 (0.087, 0.219)
–++ graduation 308 0 405 314 338
futility 0 0 0 0 0
max_n 26 0 67 18 12
n 13 (4, 36) 46 (34, 57) 10 (2, 37) 11 (4, 33) 14 (6, 37)
n_unique 12 (3, 35) 43 (31, 53) 10 (2, 35) 10 (3, 31) 12 (6, 35)
post_p 0.16 (0.03, 0.44) NA (NA, NA) 0.94 (0.57, 1) 0.18 (0.04, 0.5) 0.14 (0.03, 0.45)
rate 0.121 (0.086, 0.242) 0.073 (0.056, 0.093) 0.04 (0.022, 0.07) 0.12 (0.081, 0.258) 0.118 (0.086, 0.2)
-+– graduation 418 0 472 415 415
futility 0 0 0 0 0
max_n 24 0 18 10 16
n 7 (3, 20) 19 (10, 26) 2 (0, 10) 8 (3, 18) 6 (2, 17)
n_unique 7 (2, 19) 17 (9, 25) 1 (0, 9) 7 (3, 17) 5 (1, 15)
post_p 0.28 (0.1, 0.58) NA (NA, NA) 0.8 (0.49, 0.97) 0.27 (0.09, 0.55) 0.27 (0.1, 0.57)
rate 0.126 (0.082, 0.32) 0.076 (0.051, 0.108) 0.037 (0, 0.097) 0.125 (0.082, 0.249) 0.137 (0.077, 0.405)
-+-+ graduation 429 0 478 438 435
futility 0 0 0 0 0
max_n 23 0 18 11 16
n 7 (2, 18) 18 (11, 26) 2 (0, 7) 7 (3, 17) 6 (2, 17)
n_unique 6 (2, 17) 17 (10, 25) 1 (0, 7) 7 (2, 16) 5 (1, 16)
post_p 0.26 (0.08, 0.57) NA (NA, NA) 0.78 (0.42, 0.95) 0.26 (0.1, 0.54) 0.3 (0.11, 0.6)
rate 0.128 (0.084, 0.303) 0.072 (0.049, 0.107) 0.041 (0, 0.135) 0.125 (0.082, 0.289) 0.127 (0.075, 0.343)
-++- graduation 294 0 392 276 296
futility 0 0 0 0 0
max_n 27 0 70 18 12
n 5 (2, 12) 12 (7, 18) 2 (0, 9) 5 (2, 12) 4 (1, 11)
n_unique 5 (2, 11) 12 (7, 17) 2 (0, 8) 5 (2, 11) 4 (1, 10)
post_p 0.32 (0.15, 0.63) NA (NA, NA) 0.77 (0.41, 0.96) 0.32 (0.14, 0.62) 0.34 (0.16, 0.62)
rate 0.126 (0.073, 0.33) 0.074 (0.047, 0.121) 0.043 (0, 0.134) 0.129 (0.071, 0.359) 0.131 (0.069, 0.402)
-+++ graduation 343 0 415 346 352
futility 0 0 0 0 0
max_n 26 0 67 17 12
n 5 (1, 12) 12 (8, 17) 2 (0, 9) 5 (2, 12) 4 (1, 11)
n_unique 5 (1, 12) 12 (7, 16) 2 (0, 8) 5 (2, 11) 3 (1, 10)
post_p 0.32 (0.13, 0.61) NA (NA, NA) 0.77 (0.4, 0.94) 0.3 (0.14, 0.58) 0.34 (0.17, 0.6)
rate 0.135 (0.071, 0.361) 0.072 (0.046, 0.112) 0.043 (0.004, 0.142) 0.134 (0.073, 0.409) 0.134 (0.067, 0.468)
+— graduation 70 0 272 77 96
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 6 (2, 17) 22 (15, 28) 9 (1, 24) 6 (2, 16) 8 (3, 19)
n_unique 6 (2, 16) 21 (14, 27) 8 (1, 22) 6 (2, 15) 8 (3, 18)
post_p 0.27 (0.1, 0.57) NA (NA, NA) 0.86 (0.47, 0.99) 0.28 (0.11, 0.59) 0.23 (0.09, 0.54)
rate 0.131 (0.074, 0.355) 0.074 (0.05, 0.105) 0.041 (0.018, 0.085) 0.123 (0.071, 0.285) 0.124 (0.08, 0.252)
+–+ graduation 210 0 342 234 230
futility 0 0 0 0 0
max_n 0 0 0 1 0
n 6 (2, 14) 17 (11, 23) 5 (1, 17) 5 (2, 15) 7 (3, 15)
n_unique 5 (2, 13) 16 (10, 22) 4 (0, 15) 4 (2, 14) 6 (2, 14)
post_p 0.31 (0.13, 0.62) NA (NA, NA) 0.81 (0.46, 0.98) 0.3 (0.13, 0.58) 0.27 (0.1, 0.57)
rate 0.124 (0.067, 0.332) 0.073 (0.049, 0.11) 0.042 (0.017, 0.095) 0.128 (0.075, 0.411) 0.126 (0.075, 0.288)
+-+- graduation 234 0 371 228 269
futility 0 0 0 0 0
max_n 27 0 70 19 12
n 6 (2, 15) 17 (11, 24) 3 (0, 14) 6 (2, 16) 6 (2, 15)
n_unique 5 (2, 15) 16 (11, 22) 3 (0, 13) 6 (1, 15) 6 (2, 15)
post_p 0.31 (0.13, 0.57) NA (NA, NA) 0.8 (0.45, 0.97) 0.3 (0.12, 0.61) 0.25 (0.1, 0.57)
rate 0.122 (0.074, 0.351) 0.073 (0.046, 0.108) 0.04 (0.012, 0.098) 0.126 (0.069, 0.354) 0.134 (0.082, 0.351)
+-++ graduation 308 0 405 314 338
futility 0 0 0 0 0
max_n 26 0 67 18 12
n 6 (2, 14) 17 (11, 23) 3 (0, 14) 6 (2, 15) 6 (2, 15)
n_unique 5 (1, 13) 15 (10, 22) 3 (0, 14) 5 (1, 14) 6 (2, 15)
post_p 0.29 (0.13, 0.59) NA (NA, NA) 0.82 (0.47, 0.97) 0.31 (0.12, 0.61) 0.28 (0.1, 0.57)
rate 0.127 (0.072, 0.298) 0.073 (0.05, 0.109) 0.038 (0.014, 0.097) 0.126 (0.072, 0.339) 0.125 (0.078, 0.288)
++– graduation 206 0 319 182 169
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 5 (2, 12) 13 (8, 18) 3 (0, 12) 5 (2, 12) 4 (1, 11)
n_unique 4 (2, 11) 12 (7, 17) 3 (0, 12) 5 (2, 11) 4 (1, 10)
post_p 0.3 (0.13, 0.6) NA (NA, NA) 0.83 (0.46, 0.98) 0.3 (0.13, 0.62) 0.35 (0.15, 0.64)
rate 0.139 (0.078, 0.371) 0.078 (0.045, 0.128) 0.036 (0.011, 0.113) 0.135 (0.075, 0.371) 0.131 (0.067, 0.409)
++-+ graduation 286 0 370 298 276
futility 0 0 0 0 0
max_n 0 0 0 1 0
n 5 (2, 13) 12 (8, 18) 2 (0, 10) 5 (2, 12) 4 (1, 11)
n_unique 5 (2, 12) 12 (7, 17) 2 (0, 9) 5 (2, 11) 4 (1, 10)
post_p 0.29 (0.11, 0.61) NA (NA, NA) 0.8 (0.44, 0.96) 0.3 (0.13, 0.61) 0.34 (0.16, 0.63)
rate 0.128 (0.076, 0.367) 0.074 (0.044, 0.12) 0.04 (0.009, 0.108) 0.134 (0.076, 0.352) 0.133 (0.072, 0.401)
+++- graduation 294 0 392 276 296
futility 0 0 0 0 0
max_n 27 0 70 18 12
n 5 (2, 12) 12 (7, 18) 2 (0, 10) 5 (2, 13) 4 (1, 10)
n_unique 5 (2, 11) 12 (6, 17) 2 (0, 9) 4 (2, 11) 3 (1, 10)
post_p 0.33 (0.14, 0.61) NA (NA, NA) 0.77 (0.42, 0.96) 0.3 (0.14, 0.61) 0.33 (0.16, 0.62)
rate 0.129 (0.073, 0.32) 0.072 (0.044, 0.12) 0.039 (0.01, 0.112) 0.133 (0.073, 0.41) 0.133 (0.069, 0.512)
++++ graduation 343 0 415 346 352
futility 0 0 0 0 0
max_n 26 0 67 17 12
n 5 (2, 12) 12 (7, 18) 2 (0, 8) 5 (2, 12) 4 (1, 11)
n_unique 5 (1, 12) 12 (7, 17) 2 (0, 8) 5 (2, 12) 3 (1, 10)
post_p 0.33 (0.13, 0.62) NA (NA, NA) 0.78 (0.41, 0.95) 0.32 (0.14, 0.62) 0.34 (0.15, 0.63)
rate 0.127 (0.075, 0.378) 0.072 (0.045, 0.121) 0.042 (0, 0.122) 0.128 (0.073, 0.318) 0.133 (0.068, 0.458)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 272
time_stop 10 (4, 30)
n_trt 70 (30, 204)
n_control 110 (46, 360)
post_p 1 (0.93, 1)
order 2 (1, 3)
TP53- & AR- count 366 2 1 1
time_stop 9 (6, 26) 10 (9, 12) 12 (12, 12) 13 (13, 13)
n_trt 33 (26, 106) 29 (29, 29) 30 (30, 30) 26 (26, 26)
n_control 41 (27, 118) 35 (34, 36) 57 (57, 57) 59 (59, 59)
post_p 0.96 (0.88, 1) 0.94 (0.9, 0.97) 0.9 (0.9, 0.9) 0.88 (0.88, 0.88)
order 1 (1, 2) 2 (2, 2) 3 (3, 3) 2 (2, 2)
TP53+ count 235 1
time_stop 13 (9, 32) 9 (9, 9)
n_trt 43 (27, 126) 25 (25, 25)
n_control 64 (36, 174) 37 (37, 37)
post_p 1 (0.94, 1) 0.96 (0.96, 0.96)
order 2 (1, 4) 1 (1, 1)
DRD+ count 100 1
time_stop 24 (17, 33) 19 (19, 19)
n_trt 30 (25, 51) 28 (28, 28)
n_control 74 (47, 110) 48 (48, 48)
post_p 0.99 (0.95, 1) 0.98 (0.98, 0.98)
order 3 (1.9, 5) 3 (3, 3)
TEfus+ count 161 2
time_stop 19 (11, 33) 13 (11, 15)
n_trt 38 (26, 83) 30 (27, 33)
n_control 74 (42, 144) 48 (38, 58)
post_p 1 (0.96, 1) 0.9 (0.87, 0.93)
order 3 (2, 5) 1.5 (1.1, 1.9)
Futility:
signature var Taxel_therapies Carboplatin Niraparib Hormone_therapies
all count 96 70 77
time_stop 28 (17, 35) 30 (20, 35) 30 (20, 35)
n_trt 102 (70, 169) 110 (74, 175) 111 (76, 186)
n_control 334 (190, 418) 348 (238, 435) 346 (247, 436)
post_p 0 (0, 0) 0 (0, 0) 0 (0, 0)
order 6 (2, 9) 6 (3, 10) 6 (3, 10)
TP53- & AR- count 383 396 402 1
time_stop 21 (13, 31) 20 (13, 31) 19 (13, 32) 6 (6, 6)
n_trt 35 (25, 92) 37 (25, 102) 36 (25, 85) 26 (26, 26)
n_control 104 (60, 166) 101 (58, 162) 97 (57, 165) 26 (26, 26)
post_p 0.04 (0, 0.18) 0.05 (0, 0.21) 0.06 (0, 0.2) 0.27 (0.27, 0.27)
order 3 (1, 6) 3 (1, 6) 3 (1, 6) 1 (1, 1)
TP53+ count 263 231 225
time_stop 24 (12, 33) 26 (14, 34) 24 (14, 34)
n_trt 49 (27, 97) 54 (27, 105) 48 (28, 100)
n_control 122 (53, 191) 140 (70, 191) 129 (64, 193)
post_p 0.01 (0, 0.07) 0.01 (0, 0.07) 0.01 (0, 0.06)
order 4 (1, 8) 5 (1, 8) 3 (1, 8)
DRD+ count 137 199 182
time_stop 27 (20, 34) 25 (17, 34) 26 (16, 34)
n_trt 34 (26, 56) 42 (28, 65) 40 (27, 64)
n_control 86 (59, 114) 81 (50, 113) 80 (47, 111)
post_p 0.01 (0, 0.06) 0.01 (0, 0.05) 0.01 (0, 0.06)
order 6 (3, 9) 5 (2, 8.2) 5 (2, 8)
TEfus+ count 224 203 231
time_stop 23 (15, 33) 26 (15, 33) 26 (16, 34)
n_trt 45 (27, 81) 47 (29, 80) 45 (27, 78)
n_control 102 (55, 149) 111 (56, 150) 113 (63, 153)
post_p 0.01 (0, 0.07) 0.01 (0, 0.06) 0.01 (0, 0.05)
order 4 (1, 9) 5 (2, 9) 5 (2, 8)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 272 272 272 272 272 272 272 272 272 272 272 272 272 272 272 272
time 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30)
n 22 (13, 55) 3 (1, 8) 13 (5, 43) 6 (1, 24) 1 (0, 5) 1 (0, 5) 1 (0, 6) 1 (0, 5) 4 (0, 14) 2 (0, 9) 2 (0, 8) 2 (0, 8) 1 (0, 7) 1 (0, 6) 1 (0, 6) 1 (0, 5)
post_p 0.91 (0.64, 1) 0.7 (0.53, 0.9) 0.84 (0.6, 1) 0.72 (0.53, 0.98) 0.62 (0.52, 0.9) 0.64 (0.51, 0.88) 0.62 (0.52, 0.91) 0.68 (0.52, 0.89) 0.66 (0.52, 0.91) 0.62 (0.52, 0.93) 0.65 (0.52, 0.92) 0.64 (0.53, 0.91) 0.62 (0.52, 0.93) 0.63 (0.52, 0.91) 0.66 (0.52, 0.88) 0.64 (0.53, 0.88)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.036 (0, 0.057) 0.01 (0, 0.073) 0.033 (0, 0.058) 0.024 (0, 0.066) 0 (0, 0.07) 0 (0, 0.076) 0 (0, 0.071) 0 (0, 0.072) 0.013 (0, 0.074) 0 (0, 0.072) 0 (0, 0.078) 0 (0, 0.064) 0 (0, 0.075) 0 (0, 0.079) 0.014 (0, 0.078) 0 (0, 0.07)
DRD+ count 100 100 100 100 100 100 100 100
time 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33)
n 3 (1, 11) 3 (0, 12) 4 (1, 9) 3 (0, 8) 4 (1, 10) 4 (2, 9) 3 (1, 10) 3 (0, 8)
post_p 0.76 (0.62, 0.94) 0.78 (0.59, 0.92) 0.73 (0.55, 0.94) 0.71 (0.53, 0.9) 0.72 (0.54, 0.94) 0.75 (0.53, 0.91) 0.74 (0.53, 0.94) 0.74 (0.54, 0.88)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.026 (0, 0.063) 0.033 (0, 0.06) 0.032 (0, 0.072) 0.029 (0, 0.079) 0.03 (0, 0.07) 0.029 (0, 0.072) 0.029 (0, 0.07) 0.031 (0, 0.071)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19)
n 2 (2, 2) 5 (5, 5) 5 (5, 5) 4 (4, 4) 3 (3, 3) 0 (0, 0) 5 (5, 5) 4 (4, 4)
post_p 0.52 (0.52, 0.52) 0.74 (0.74, 0.74) 0.84 (0.84, 0.84) 0.68 (0.68, 0.68) 0.62 (0.62, 0.62) NA (NA, NA) 0.76 (0.76, 0.76) 0.64 (0.64, 0.64)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.082 (0.082, 0.082) 0.087 (0.087, 0.087) 0.026 (0.026, 0.026) 0 (0, 0) 0.056 (0.056, 0.056) NA (NA, NA) 0.024 (0.024, 0.024) 0.033 (0.033, 0.033)
TEfus+ Hormone_therapies count 161 161 161 161 161 161 161 161
time 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33)
n 5 (2, 11) 13 (6, 32) 2 (0, 7) 2 (0, 7) 5 (1, 13) 4 (2, 12) 3 (0, 8) 3 (0, 6)
post_p 0.8 (0.56, 0.95) 0.88 (0.71, 0.99) 0.72 (0.55, 0.9) 0.73 (0.52, 0.88) 0.72 (0.52, 0.94) 0.77 (0.55, 0.94) 0.71 (0.54, 0.91) 0.69 (0.53, 0.87)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.031 (0, 0.071) 0.035 (0.008, 0.06) 0.03 (0, 0.073) 0.019 (0, 0.062) 0.035 (0, 0.074) 0.028 (0, 0.063) 0.019 (0, 0.078) 0.025 (0, 0.07)
Niraparib count 2 2 2 2 2 2 2 2
time 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15)
n 4 (2, 5) 5 (3, 7) 8 (6, 10) 2 (1, 4) 2 (2, 3) 2 (1, 2) 2 (2, 3) 4 (4, 5)
post_p 0.56 (0.54, 0.57) 0.67 (0.54, 0.79) 0.84 (0.78, 0.9) 0.52 (0.52, 0.52) 0.54 (0.52, 0.57) 0.56 (0.52, 0.59) 0.54 (0.52, 0.57) 0.59 (0.55, 0.63)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.109 (0.062, 0.157) 0 (0, 0) 0.025 (0.005, 0.046) 0.041 (0.041, 0.041) 0.028 (0.006, 0.051) 0.035 (0.007, 0.062) 0.085 (0.082, 0.089) 0.054 (0.05, 0.058)
TP53- & AR- Carboplatin count 1 1 1 1
time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
n 14 (14, 14) 3 (3, 3) 3 (3, 3) 10 (10, 10)
post_p 0.71 (0.71, 0.71) 0.62 (0.62, 0.62) 0.56 (0.56, 0.56) 0.8 (0.8, 0.8)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.029 (0.029, 0.029) 0 (0, 0) 0.063 (0.063, 0.063) 0.032 (0.032, 0.032)
Hormone_therapies count 366 366 366 366
time 9 (6, 26) 9 (6, 26) 9 (6, 26) 9 (6, 26)
n 26 (20, 74) 4 (2, 11) 2 (0, 9) 2 (0, 6)
post_p 0.9 (0.75, 1) 0.71 (0.54, 0.87) 0.61 (0.52, 0.85) 0.61 (0.51, 0.83)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.035 (0.016, 0.055) 0.024 (0, 0.074) 0 (0, 0.062) 0 (0, 0.072)
Niraparib count 1 1 1 1
time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
n 10 (10, 10) 3 (3, 3) 4 (4, 4) 9 (9, 9)
post_p 0.72 (0.72, 0.72) 0.56 (0.56, 0.56) 0.56 (0.56, 0.56) 0.84 (0.84, 0.84)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.041 (0.041, 0.041) 0 (0, 0) 0.08 (0.08, 0.08) 0.036 (0.036, 0.036)
Taxel_therapies count 2 2 2 2
time 10 (9, 12) 10 (9, 12) 10 (9, 12) 10 (9, 12)
n 20 (18, 21) 4 (4, 5) 2 (2, 2) 3 (2, 4)
post_p 0.79 (0.72, 0.86) 0.65 (0.61, 0.69) 0.6 (0.52, 0.68) 0.74 (0.74, 0.74)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.038 (0.024, 0.052) 0.067 (0.055, 0.08) 0.044 (0.009, 0.079) 0 (0, 0)
TP53+ Hormone_therapies count 235 235 235 235 235 235 235 235
time 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32)
n 20 (12, 53) 10 (4, 28) 2 (0, 6) 2 (0, 6) 3 (0, 10) 3 (1, 11) 2 (0, 6) 2 (0, 6)
post_p 0.91 (0.75, 1) 0.83 (0.61, 0.99) 0.62 (0.52, 0.87) 0.66 (0.52, 0.87) 0.7 (0.52, 0.93) 0.72 (0.53, 0.91) 0.65 (0.52, 0.9) 0.63 (0.53, 0.87)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.035 (0.013, 0.056) 0.033 (0, 0.063) 0 (0, 0.075) 0 (0, 0.071) 0.02 (0, 0.078) 0.018 (0, 0.064) 0 (0, 0.065) 0 (0, 0.078)
Niraparib count 1 1 1 1 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 5 (5, 5) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 2 (2, 2) 0 (0, 0) 2 (2, 2)
post_p 0.74 (0.74, 0.74) 0.64 (0.64, 0.64) 0.65 (0.65, 0.65) 0.74 (0.74, 0.74) 0.61 (0.61, 0.61) 0.57 (0.57, 0.57) NA (NA, NA) 0.63 (0.63, 0.63)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.053 (0.053, 0.053) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Carboplatin count 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70
time 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35)
n 18 (8, 51) 4 (2, 13) 11 (5, 43) 8 (3, 22) 6 (2, 15) 6 (2, 15) 4 (1, 9) 3 (1, 8) 4 (2, 10) 3 (1, 8) 4 (1, 12) 4 (1, 10) 4 (1, 8) 4 (1, 8) 4 (1, 10) 4 (1, 10)
post_p 0.11 (0.02, 0.34) 0.29 (0.13, 0.45) 0.21 (0.06, 0.36) 0.24 (0.06, 0.4) 0.31 (0.12, 0.45) 0.31 (0.09, 0.46) 0.3 (0.18, 0.44) 0.31 (0.17, 0.42) 0.27 (0.11, 0.42) 0.32 (0.18, 0.45) 0.31 (0.11, 0.46) 0.28 (0.14, 0.43) 0.33 (0.17, 0.48) 0.3 (0.09, 0.47) 0.29 (0.18, 0.45) 0.32 (0.1, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.117 (0.086, 0.16) 0.149 (0.082, 0.51) 0.122 (0.09, 0.194) 0.126 (0.089, 0.374) 0.133 (0.087, 0.554) 0.135 (0.089, 0.311) 0.149 (0.093, 0.314) 0.178 (0.094, 0.456) 0.146 (0.102, 0.476) 0.14 (0.084, 0.452) 0.136 (0.084, 0.336) 0.168 (0.099, 0.608) 0.142 (0.097, 0.634) 0.144 (0.095, 0.492) 0.134 (0.084, 0.479) 0.144 (0.09, 0.5)
Niraparib count 77 77 77 77 77 77 77 77 77 77 77 77 77 77 77 77
time 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35)
n 20 (8, 57) 5 (1, 13) 11 (4, 40) 7 (4, 21) 6 (3, 12) 6 (3, 14) 4 (2, 9) 4 (1, 8) 5 (2, 12) 4 (1, 8) 4 (1, 12) 3 (1, 8) 4 (1, 8) 3 (1, 8) 4 (2, 8) 4 (2, 7)
post_p 0.1 (0.01, 0.29) 0.32 (0.14, 0.47) 0.17 (0.06, 0.4) 0.24 (0.1, 0.45) 0.31 (0.13, 0.47) 0.24 (0.12, 0.44) 0.31 (0.16, 0.47) 0.29 (0.13, 0.44) 0.29 (0.12, 0.47) 0.29 (0.16, 0.47) 0.32 (0.14, 0.44) 0.32 (0.11, 0.45) 0.31 (0.14, 0.46) 0.3 (0.17, 0.48) 0.32 (0.17, 0.46) 0.3 (0.16, 0.43)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.119 (0.094, 0.172) 0.123 (0.082, 0.604) 0.118 (0.086, 0.266) 0.117 (0.076, 0.255) 0.125 (0.087, 0.215) 0.143 (0.087, 0.311) 0.139 (0.09, 0.405) 0.148 (0.095, 0.453) 0.134 (0.081, 0.374) 0.16 (0.09, 0.658) 0.152 (0.089, 0.354) 0.145 (0.09, 0.527) 0.162 (0.098, 0.393) 0.179 (0.104, 0.438) 0.127 (0.085, 0.342) 0.145 (0.094, 0.455)
Taxel_therapies count 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96
time 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35)
n 16 (6, 36) 6 (2, 12) 11 (5, 27) 10 (5, 28) 4 (1, 11) 4 (0, 12) 3 (0, 8) 2 (0, 6) 6 (3, 16) 5 (2, 10) 6 (2, 12) 5 (2, 10) 3 (1, 7) 3 (1, 7) 3 (0, 8) 2 (0, 6)
post_p 0.12 (0.02, 0.33) 0.25 (0.12, 0.45) 0.19 (0.07, 0.44) 0.19 (0.04, 0.42) 0.27 (0.15, 0.47) 0.28 (0.1, 0.45) 0.32 (0.18, 0.48) 0.3 (0.17, 0.46) 0.29 (0.09, 0.45) 0.28 (0.13, 0.44) 0.27 (0.13, 0.46) 0.27 (0.14, 0.45) 0.35 (0.17, 0.45) 0.32 (0.17, 0.46) 0.33 (0.14, 0.46) 0.34 (0.2, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.122 (0.085, 0.213) 0.135 (0.083, 0.3) 0.122 (0.091, 0.198) 0.124 (0.089, 0.199) 0.156 (0.085, 0.456) 0.164 (0.09, 0.366) 0.148 (0.081, 0.358) 0.157 (0.095, 0.7) 0.137 (0.087, 0.275) 0.141 (0.082, 0.341) 0.13 (0.083, 0.267) 0.141 (0.088, 0.318) 0.157 (0.09, 0.453) 0.165 (0.084, 0.562) 0.155 (0.081, 0.487) 0.145 (0.083, 0.482)
DRD+ Carboplatin count 199 199 199 199 199 199 199 199
time 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34)
n 6 (2, 15) 6 (2, 15) 5 (2, 10) 4 (1, 9) 4 (1, 9) 4 (1, 10) 4 (1, 9) 4 (2, 10)
post_p 0.32 (0.12, 0.47) 0.27 (0.11, 0.47) 0.33 (0.16, 0.47) 0.34 (0.15, 0.46) 0.33 (0.15, 0.47) 0.35 (0.13, 0.47) 0.34 (0.16, 0.47) 0.32 (0.14, 0.48)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.122 (0.083, 0.327) 0.134 (0.088, 0.311) 0.141 (0.093, 0.351) 0.157 (0.085, 0.388) 0.14 (0.087, 0.452) 0.134 (0.084, 0.398) 0.138 (0.08, 0.431) 0.144 (0.087, 0.43)
Niraparib count 182 182 182 182 182 182 182 182
time 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34)
n 7 (3, 15) 6 (3, 14) 4 (2, 10) 4 (1, 10) 4 (1, 9) 4 (1, 10) 4 (1, 10) 4 (2, 9)
post_p 0.3 (0.11, 0.47) 0.31 (0.12, 0.45) 0.31 (0.16, 0.46) 0.3 (0.18, 0.48) 0.31 (0.15, 0.47) 0.32 (0.15, 0.48) 0.34 (0.16, 0.45) 0.34 (0.17, 0.47)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.129 (0.085, 0.244) 0.127 (0.09, 0.281) 0.146 (0.089, 0.404) 0.143 (0.083, 0.461) 0.158 (0.097, 0.394) 0.153 (0.088, 0.378) 0.145 (0.085, 0.454) 0.145 (0.085, 0.362)
Taxel_therapies count 137 137 137 137 137 137 137 137
time 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34)
n 5 (2, 13) 5 (2, 13) 3 (1, 9) 3 (1, 7) 3 (1, 8) 3 (1, 9) 4 (1, 9) 3 (1, 8)
post_p 0.3 (0.12, 0.47) 0.3 (0.12, 0.46) 0.33 (0.18, 0.48) 0.35 (0.19, 0.48) 0.36 (0.17, 0.46) 0.32 (0.18, 0.46) 0.34 (0.18, 0.46) 0.34 (0.19, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.151 (0.083, 0.4) 0.142 (0.081, 0.383) 0.149 (0.083, 0.48) 0.139 (0.087, 0.516) 0.15 (0.091, 0.395) 0.154 (0.087, 0.444) 0.141 (0.087, 0.649) 0.15 (0.081, 0.468)
TEfus+ Carboplatin count 203 203 203 203 203 203 203 203
time 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33)
n 5 (2, 13) 9 (3, 25) 6 (2, 15) 4 (1, 9) 4 (1, 11) 4 (1, 13) 4 (2, 10) 4 (2, 10)
post_p 0.32 (0.14, 0.47) 0.24 (0.07, 0.43) 0.3 (0.09, 0.46) 0.31 (0.14, 0.45) 0.31 (0.17, 0.47) 0.33 (0.15, 0.47) 0.32 (0.13, 0.47) 0.33 (0.14, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.132 (0.078, 0.358) 0.121 (0.088, 0.291) 0.131 (0.086, 0.307) 0.152 (0.082, 0.496) 0.138 (0.08, 0.423) 0.137 (0.087, 0.397) 0.136 (0.087, 0.443) 0.135 (0.085, 0.433)
Niraparib count 231 231 231 231 231 231 231 231
time 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34)
n 4 (2, 13) 9 (3, 25) 7 (3, 15) 4 (1, 9) 4 (1, 9) 4 (1, 10) 4 (1, 10) 4 (2, 10)
post_p 0.33 (0.12, 0.47) 0.23 (0.09, 0.45) 0.3 (0.12, 0.46) 0.33 (0.14, 0.47) 0.33 (0.15, 0.47) 0.34 (0.15, 0.46) 0.31 (0.15, 0.47) 0.32 (0.16, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.133 (0.084, 0.419) 0.121 (0.085, 0.29) 0.134 (0.087, 0.298) 0.145 (0.086, 0.45) 0.147 (0.083, 0.594) 0.14 (0.084, 0.386) 0.14 (0.081, 0.408) 0.139 (0.087, 0.339)
Taxel_therapies count 224 224 224 224 224 224 224 224
time 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33)
n 5 (2, 12) 11 (6, 29) 4 (1, 13) 3 (1, 7) 5 (2, 12) 5 (2, 11) 3 (1, 8) 3 (1, 7)
post_p 0.29 (0.12, 0.45) 0.2 (0.04, 0.45) 0.33 (0.13, 0.46) 0.34 (0.19, 0.46) 0.3 (0.13, 0.46) 0.32 (0.13, 0.47) 0.35 (0.17, 0.46) 0.35 (0.17, 0.48)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.138 (0.087, 0.341) 0.123 (0.089, 0.201) 0.144 (0.081, 0.446) 0.148 (0.085, 0.577) 0.138 (0.086, 0.354) 0.132 (0.086, 0.3) 0.154 (0.082, 0.487) 0.155 (0.082, 0.544)
TP53- & AR- Carboplatin count 396 396 396 396
time 20 (13, 31) 20 (13, 31) 20 (13, 31) 20 (13, 31)
n 20 (8, 66) 5 (2, 13) 7 (3, 15) 6 (2, 15)
post_p 0.18 (0.02, 0.44) 0.34 (0.16, 0.48) 0.34 (0.15, 0.48) 0.33 (0.11, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.114 (0.085, 0.182) 0.129 (0.075, 0.345) 0.121 (0.082, 0.33) 0.135 (0.081, 0.326)
Hormone_therapies count 1 1 1 1
time 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6)
n 22 (22, 22) 3 (3, 3) 1 (1, 1) 0 (0, 0)
post_p 0.36 (0.36, 0.36) 0.16 (0.16, 0.16) 0.44 (0.44, 0.44) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.078 (0.078, 0.078) 0.284 (0.284, 0.284) 0 (0, 0) NA (NA, NA)
Niraparib count 402 402 402 402
time 19 (13, 32) 19 (13, 32) 19 (13, 32) 19 (13, 32)
n 18 (8, 55) 5 (2, 13) 7 (3, 15) 6 (3, 13)
post_p 0.21 (0.03, 0.43) 0.35 (0.16, 0.48) 0.34 (0.13, 0.48) 0.32 (0.12, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.109 (0.083, 0.194) 0.124 (0.077, 0.464) 0.125 (0.085, 0.279) 0.129 (0.085, 0.314)
Taxel_therapies count 383 383 383 383
time 21 (13, 31) 21 (13, 31) 21 (13, 31) 21 (13, 31)
n 19 (10, 55) 6 (2, 15) 5 (2, 14) 5 (2, 14)
post_p 0.16 (0.02, 0.43) 0.33 (0.13, 0.47) 0.32 (0.15, 0.47) 0.36 (0.16, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.117 (0.086, 0.18) 0.123 (0.08, 0.299) 0.145 (0.083, 0.429) 0.132 (0.078, 0.422)
TP53+ Carboplatin count 231 231 231 231 231 231 231 231
time 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34)
n 12 (5, 40) 9 (3, 27) 4 (1, 10) 4 (1, 10) 4 (1, 13) 4 (1, 13) 4 (1, 9) 4 (2, 10)
post_p 0.19 (0.03, 0.43) 0.23 (0.06, 0.45) 0.32 (0.16, 0.46) 0.33 (0.17, 0.47) 0.33 (0.16, 0.47) 0.33 (0.14, 0.47) 0.34 (0.17, 0.47) 0.33 (0.16, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.122 (0.086, 0.23) 0.129 (0.087, 0.298) 0.141 (0.085, 0.366) 0.149 (0.08, 0.465) 0.136 (0.085, 0.43) 0.133 (0.082, 0.413) 0.139 (0.085, 0.415) 0.134 (0.078, 0.425)
Niraparib count 225 225 225 225 225 225 225 225
time 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34)
n 11 (5, 40) 8 (3, 24) 4 (2, 10) 4 (1, 9) 4 (1, 11) 4 (1, 11) 4 (1, 9) 4 (2, 9)
post_p 0.22 (0.05, 0.44) 0.23 (0.08, 0.46) 0.34 (0.16, 0.48) 0.32 (0.16, 0.47) 0.35 (0.17, 0.48) 0.34 (0.15, 0.47) 0.33 (0.15, 0.47) 0.33 (0.18, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.115 (0.084, 0.239) 0.121 (0.086, 0.288) 0.137 (0.079, 0.383) 0.146 (0.081, 0.461) 0.138 (0.076, 0.357) 0.138 (0.079, 0.381) 0.143 (0.082, 0.454) 0.138 (0.085, 0.374)
Taxel_therapies count 263 263 263 263 263 263 263 263
time 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33)
n 12 (5, 33) 11 (6, 27) 3 (1, 8) 3 (1, 8) 5 (2, 14) 5 (2, 11) 3 (1, 8) 3 (0, 8)
post_p 0.19 (0.05, 0.43) 0.19 (0.04, 0.43) 0.35 (0.18, 0.48) 0.37 (0.21, 0.48) 0.3 (0.13, 0.46) 0.32 (0.14, 0.48) 0.35 (0.18, 0.48) 0.35 (0.18, 0.47)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.121 (0.083, 0.217) 0.124 (0.086, 0.216) 0.157 (0.077, 0.491) 0.143 (0.082, 0.526) 0.134 (0.084, 0.345) 0.135 (0.085, 0.296) 0.149 (0.071, 0.769) 0.155 (0.084, 0.602)